Sweat Hypersensitivity Type Cu

Sweat hypersensitivity Type CU
Specialty	Dermatology

Sweat hypersensitivity is a type of Cholinergic urticaria which refers to those who are hypersensitive to their own sweat.^[1]

Signs and symptoms[edit | edit source]

The hives are observed to coincide with perspiration points of sweating.^[2]

Pathophysiology[edit | edit source]

Tanaka et al. found that the sweat hyper-sensitivities of CU and atopic dermatitis seem to be virtually the same, and therefore, the sweat-induced histamine release from basophils may also be mediated by a specific IgE for sweat in atopic dermatitis as well as CU.^[2]

Diagnosis[edit | edit source]

Diagnosis is made by injecting autologous (the person's own) sweat into the skin.^[3]

Treatment[edit | edit source]

• Proposed first-line treatment: Rapid desensitization protocol using autologous sweat.^[3]
• Non-pharmacological treatment: Forced perspiration by excessive body warming (hot bath or exercise) used daily may reduce the symptoms through exhaustion of inflammatory mediators.^[4] This non-pharmacological treatment is contraindicated in those with CU as a result of hypohidrosis (see below).
• Antihistamines are a commonly prescribed first-line treatment for conventional urticaria, but its effectiveness in the treatment of CU is rather limited in most cases. Some research suggests that first-generation antihistamines with anticholinergic properties such as diphenhydramine are most successful at treating CU.^{[citation needed]}
• Treatment(s) with mixed success: omalizumab (anti-IgE therapy),^[5][6] danazol (synthetic androgen),^[7] propranolol (beta blocker),^[8][9] zileuton (antileukotriene).

References[edit | edit source]