Mark2

From Handwiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Serine/threonine-protein kinase MARK2 is an enzyme that in humans is encoded by the MARK2 gene.[1][2][3]

Function

EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.[3]

Interactions

MARK2 has been shown to interact with AKT1.[4]

References

  1. ↑ "Human serine/threonine protein kinase EMK1: genomic structure and cDNA cloning of isoforms produced by alternative splicing". Cytogenet Cell Genet 81 (3–4): 278–82. Oct 1998. doi:10.1159/000015046. PMID 9730619. 
  2. ↑ "Precise localization of D11S1226 to the human EMK1 gene at chromosome band 11q13 by sequence homology search". Cytogenet Cell Genet 86 (1): 66–7. Oct 1999. doi:10.1159/000015413. PMID 10516437. 
  3. ↑ 3.0 3.1 "Entrez Gene: MARK2 MAP/microtubule affinity-regulating kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2011. 
  4. ↑ "Akt and CHIP coregulate tau degradation through coordinated interactions". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3622–7. Mar 2008. doi:10.1073/pnas.0709180105. PMID 18292230. Bibcode: 2008PNAS..105.3622D. 

Further reading

  • "Human EMK1 is located on 11q12-q13, close to COX8 and FTH1". Mamm. Genome 6 (4): 311–2. 1995. doi:10.1007/BF00352433. PMID 7613050. 
  • "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. 1994. PMID 8274451. 
  • "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • "Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1)". Genomics 37 (3): 354–65. 1997. doi:10.1006/geno.1996.0570. PMID 8938448. 
  • "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. 1997. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484. 
  • "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • "PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling". Nat. Cell Biol. 3 (7): 628–36. 2001. doi:10.1038/35083016. PMID 11433294. 
  • "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. 2004. doi:10.1074/jbc.M312171200. PMID 14676191. 
  • "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. 2004. doi:10.1038/ncb1086. PMID 14743216. 
  • "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. 2005. doi:10.1038/sj.emboj.7600110. PMID 14976552. 
  • "Splicing alterations in human renal allografts: detection of a new splice variant of protein kinase Par1/Emk1 whose expression is associated with an increase of inflammation in protocol biopsies of transplanted patients". Biochim. Biophys. Acta 1689 (1): 58–65. 2004. doi:10.1016/j.bbadis.2004.01.008. PMID 15158914. 
  • "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B. 
  • "aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity". Curr. Biol. 14 (16): 1425–35. 2004. doi:10.1016/j.cub.2004.08.021. PMID 15324659. 
  • "Par-1 promotes a hepatic mode of apical protein trafficking in MDCK cells". Proc. Natl. Acad. Sci. U.S.A. 101 (38): 13792–7. 2004. doi:10.1073/pnas.0403684101. PMID 15365179. Bibcode: 2004PNAS..10113792C. 
  • "Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1". Cancer Res. 64 (20): 7361–9. 2004. doi:10.1158/0008-5472.CAN-04-0823. PMID 15492257. 




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