Ethanolamine-O-Sulfate

Ethanolamine-O-sulfate^[1]
Names
	Preferred IUPAC name 2-Aminoethyl hydrogen sulfate
	Other names Aminoethyl sulfate; 2-Aminoethyl hydrogen sulphate; Sulfuric acid mono 2-aminoethyl ester; WAS-34
Identifiers
CAS Number	926-39-6 ;
3D model (JSmol)	Interactive image;
Abbreviations	EOS
ChemSpider	63409 ;
EC Number	213-135-7;
PubChem CID	5245535;
UNII	9C8F910HLK ;
	InChI InChI=1S/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6) Key: WSYUEVRAMDSJKL-UHFFFAOYSA-N ;
	SMILES C(COS(=O)(=O)O)N;
Properties
Chemical formula	C2H7NO4S
Molar mass	141.14 g·mol−1
Melting point	277 °C (531 °F; 550 K) (decomposes)
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302, H315, H319, H335
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Ethanolamine-O-sulfate (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents the metabolism of GABA.^[2] It is used as a biochemical tool in studies involving GABA.

EOS is also a diuretic^[3] and an anticonvulsant.^[4]

References

↑ 2-Aminoethyl hydrogen sulfate at Sigma-Aldrich
↑ "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations". Neuroendocrinology 37 (5): 397–9. 1983. doi:10.1159/000123580. PMID 6646351.
↑ German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974)
↑ Anlezark, Gill; Horton, Roger W.; Meldrum, Brian S.; Sawaya, M. Christina B. (1976). "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures". Biochemical Pharmacology 25 (4): 413–417. doi:10.1016/0006-2952(76)90343-9. PMID 779794.

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[1] 2-Aminoethyl hydrogen sulfate at Sigma-Aldrich

[2] "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations". Neuroendocrinology 37 (5): 397–9. 1983. doi:10.1159/000123580. PMID 6646351.

[3] German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974)

[4] Anlezark, Gill; Horton, Roger W.; Meldrum, Brian S.; Sawaya, M. Christina B. (1976). "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures". Biochemical Pharmacology 25 (4): 413–417. doi:10.1016/0006-2952(76)90343-9. PMID 779794.