Parathyroid Hormone Receptor

From Handwiki
Short description: none
parathyroid hormone 1 receptor
Identifiers
SymbolPTH1R
Alt. symbolsPTHR, PFE
NCBI gene5745
HGNC9608
OMIM168468
RefSeqNM_000316
UniProtQ03431
Other data
LocusChr. 3 p22-p21.1
parathyroid hormone 2 receptor
Identifiers
SymbolPTH2R
NCBI gene5746
HGNC9609
OMIM601469
RefSeqNM_005048
UniProtP49190
Other data
LocusChr. 2 q33

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors bind parathyroid hormone and are members of the GPCR family of transmembrane proteins.[1]

  • parathyroid hormone 1 receptor (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[2][3]
  • parathyroid hormone 2 receptor (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.[4]

References

  1. ↑ Jüppner H (1994). "Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors". Curr. Opin. Nephrol. Hypertens. 3 (4): 371–8. doi:10.1097/00041552-199407000-00002. PMID 8076140. 
  2. ↑ "Receptors for PTH and PTHrP: their biological importance and functional properties". Am. J. Physiol. 277 (5 Pt 2): F665–75. 1999. doi:10.1152/ajprenal.1999.277.5.F665. PMID 10564229. http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665. Retrieved 2007-11-01. 
  3. ↑ "G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells". Mol. Endocrinol. 10 (5): 566–74. 1996. doi:10.1210/mend.10.5.8732687. PMID 8732687. 
  4. ↑ "The parathyroid hormone 2 (PTH2) receptor". Recept. Channels 8 (3–4): 211–8. 2002. doi:10.1080/10606820213682. PMID 12529938. 

External links

  • Parathyroid+Hormone+Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
  • "Parathyroid Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1327. 




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Categories: [G protein-coupled receptors]

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