Testosterone 5-Alpha-Reductase

Benign prostatic hypertrophy[edit]

Inhibitors are finasteride and dutasteride are used to treat benign prostatic hypertrophy. Both of these medications are metaoblized by cytochrome P-450 CYP3A4.Dutasteride may better prevent acute urinary retention rates than finasteride effective according to a cohort study.^[1] may better lower dihydrotestosterone.^[2] It may also better reduce symptoms in preliminary trial.^[3]

Developmental androgen disorders[edit]

Both testosterone 5-alpha-reductase deficiency and androgen receptor insensitivity involve this enzyme. The differential diagnosis can be difficult. ^[4]

References[edit]

↑ Fenter TC, Davis EA, Shah MB, Lin PJ (2008). "Dutasteride vs finasteride: assessment of differences in acute urinary retention rates and surgical risk outcomes in an elderly population aged > or =65 years.". Am J Manag Care 14 (5 Suppl 2): S154-9. PMID 18611089.
↑ Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S (2004). "Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor.". J Clin Endocrinol Metab 89 (5): 2179-84. PMID 15126539.
↑ Ravish IR, Nerli RB, Amarkhed SS (2007 Jan-Feb). "Finasteride to evaluate the efficacy of dutasteride in the management of patients with lower urinary tract symptoms and enlarged prostate.". Arch Androl 53 (1): 17-20. DOI:10.1080/01485010600888953. PMID 17364459. Research Blogging.
↑ E T George, S Alvi, N K Taylor & T Mushtaq (2009), "Diagnostic Challenges in Androgen Insensitivity Syndrome & 5 Alpha Reductase Deficiency", Endocrine Abstracts 23: P25

[pmid18611089-1] Fenter TC, Davis EA, Shah MB, Lin PJ (2008). "Dutasteride vs finasteride: assessment of differences in acute urinary retention rates and surgical risk outcomes in an elderly population aged > or =65 years.". Am J Manag Care 14 (5 Suppl 2): S154-9. PMID 18611089.

[pmid15126539-2] Clark RV, Hermann DJ, Cunningham GR, Wilson TH, Morrill BB, Hobbs S (2004). "Marked suppression of dihydrotestosterone in men with benign prostatic hyperplasia by dutasteride, a dual 5alpha-reductase inhibitor.". J Clin Endocrinol Metab 89 (5): 2179-84. PMID 15126539.

[pmid17364459-3] Ravish IR, Nerli RB, Amarkhed SS (2007 Jan-Feb). "Finasteride to evaluate the efficacy of dutasteride in the management of patients with lower urinary tract symptoms and enlarged prostate.". Arch Androl 53 (1): 17-20. DOI:10.1080/01485010600888953. PMID 17364459. Research Blogging.

[4] E T George, S Alvi, N K Taylor & T Mushtaq (2009), "Diagnostic Challenges in Androgen Insensitivity Syndrome & 5 Alpha Reductase Deficiency", Endocrine Abstracts 23: P25

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