Th-Pvp

TH-PVP
Clinical data
ATC code	None;
Legal status
Legal status	BR: F2 ; CA: Schedule I ; DE: NpSG (Industrial and scientific use only) ; UK: Under Psychoactive Substances Act ;
Identifiers
	IUPAC name 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one;
CAS Number	2304915-07-7 ;
PubChem CID	132989549;
ChemSpider	82954253;
UNII	S5MU9GV87C;
Chemical and physical data
Formula	C19H27NO
Molar mass	285.431 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC(C(=O)C1=CC2=C(CCCC2)C=C1)N3CCCC3;
	InChI InChI=1S/C19H27NO/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17/h10-11,14,18H,2-9,12-13H2,1H3; Key:MMIKQWIZKBYLKZ-UHFFFAOYSA-N;

Short description: Chemical compound

TH-PVP is a substituted cathinone derivative which has been sold as a designer drug. It was first identified by a forensic laboratory in Hungary in 2015,^[1] but has subsequently been found in numerous other countries around the world including Spain, Belgium, Poland, Turkey and Brazil.^[2]^[3]^[4]^[5]^[6]^[7] Pharmacological studies in vitro showed it to inhibit reuptake and promote the release of monoamine neurotransmitters with some selectivity for serotonin,^[8] but it failed to produce stimulant effects in animals,^[9] and has a pharmacological profile more comparable to that of sedating empathogens such as MDAI and 5-Methyl-MDA.

References

↑ "EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA". http://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf.
↑ "Identification and derivatization of selected cathinones by spectroscopic studies". Forensic Science International 266: 416–426. September 2016. doi:10.1016/j.forsciint.2016.06.034. PMID 27423024.
↑ "Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances". Journal of Chromatography A 1574: 91–100. November 2018. doi:10.1016/j.chroma.2018.09.006. PMID 30220430.
↑ "Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population". Drug Testing and Analysis 10 (3): 539–547. March 2018. doi:10.1002/dta.2232. PMID 28640970.
↑ "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone.". Forensic Toxicol 37 (2): 288–307. July 2019. doi:10.1007/s11419-018-00463-w.
↑ "New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey". Forensic Science International 294: 113–123. January 2019. doi:10.1016/j.forsciint.2018.11.003. PMID 30502695.
↑ "New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study.". Forensic Science International 306: 110002. 24 October 2019. doi:10.1016/j.forsciint.2019.110002. PMID 31864775.
↑ "Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology 236 (3): 939–952. March 2019. doi:10.1007/s00213-018-5059-5. PMID 30397775.
↑ "Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats". Drug and Alcohol Dependence 199: 50–58. June 2019. doi:10.1016/j.drugalcdep.2019.02.016. PMID 30986635.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/TH-PVP. Read more

[1] "EMCDDA–Europol 2015 Annual Report on the implementation of Council Decision 2005/387/JHA". http://www.emcdda.europa.eu/system/files/publications/2880/TDAS16001ENN.pdf.

[pmid27423024-2] "Identification and derivatization of selected cathinones by spectroscopic studies". Forensic Science International 266: 416–426. September 2016. doi:10.1016/j.forsciint.2016.06.034. PMID 27423024.

[pmid30220430-3] "Ion mobility spectrometry and high resolution mass-spectrometry as methodologies for rapid identification of the last generation of new psychoactive substances". Journal of Chromatography A 1574: 91–100. November 2018. doi:10.1016/j.chroma.2018.09.006. PMID 30220430.

[pmid28640970-4] "Prevalence of new psychoactive substances and prescription drugs in the Belgian driving under the influence of drugs population". Drug Testing and Analysis 10 (3): 539–547. March 2018. doi:10.1002/dta.2232. PMID 28640970.

[5] "Identification and structural characterization of synthetic cathinones: N-propylcathinone, 2,4-dimethylmethcathinone, 2,4-dimethylethcathinone, 2,4-dimethyl-α-pyrrolidinopropiophenone, 4-bromo-α-pyrrolidinopropiophenone, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidin-1-yl)hexan-1-one and 2,4-dimethylisocathinone.". Forensic Toxicol 37 (2): 288–307. July 2019. doi:10.1007/s11419-018-00463-w.

[pmid30502695-6] "New psychoactive substances in Turkey: Narcotics cases assessed by the Council of Forensic Medicine between 2016 and 2017 in Ankara, Turkey". Forensic Science International 294: 113–123. January 2019. doi:10.1016/j.forsciint.2018.11.003. PMID 30502695.

[7] "New psychoactive substances (NPS) prevalence over LSD in blotter seized in State of Santa Catarina, Brazil: a six-year retrospective study.". Forensic Science International 306: 110002. 24 October 2019. doi:10.1016/j.forsciint.2019.110002. PMID 31864775.

[pmid30397775-8] "Structure-activity relationships of bath salt components: substituted cathinones and benzofurans at biogenic amine transporters". Psychopharmacology 236 (3): 939–952. March 2019. doi:10.1007/s00213-018-5059-5. PMID 30397775.

[pmid30986635-9] "Locomotor activity and discriminative stimulus effects of five novel synthetic cathinone analogs in mice and rats". Drug and Alcohol Dependence 199: 50–58. June 2019. doi:10.1016/j.drugalcdep.2019.02.016. PMID 30986635.

v t e Empathogens/entactogens
Phenylalkyl- amines (other than cathinones)	Unfused benzene ring: 3-CMA 4-CAB 4-FA 4-MA 4-MMA 4-FMA 4-MTA 4,4'-DMAR Ariadne Metaescaline MMA PMA PMEA PMMA mMMA Benzodioxine: EDMA Benzodioxoles: Phenethylamine: { Lophophine } Amphetamines: { 2-Methyl-MDA 2,3-MDA 3,4-MDA (tenamfetamine) 5-Methyl-MDA 6-Methyl-MDA DiFMDA DMMDA DMMDA-2 EIDA MDEA MDMA (midomafetamine) MDMOH MDOH MMDA MMDA-2 MMDMA } 1-Phenylbutan-2-amines: { BDB EBDB MBDB } Phentermines: { MDMP MDPH } Benzofurans and dihydrobenzofurans: 5-APB 5-APDB 5-EAPB 5-MAPB 5-MAPDB 5-MBPB 6-APB 6-APDB 6-EAPB 6-MAPB 6-MAPDB IBF5MAP Indanes: 5-APDI 5-MAPDI Indoles: 5-IT 6-API Naphthalenes: Methamnetamine Naphthylaminopropane Tetralin: 6-APT
Cyclized phenyl- alkylamines	Aminoindanes: 5-IAI AMMI ETAI MDAI MDMAI MMAI MEAI NM-2-AI TAI Aminotetralins: 6-CAT MDAT MDMAT
Cathinones	3-MMC 4-EMC Brephedrone Butylone Ethylone Eutylone Flephedrone Mephedrone Methedrone Methylone TH-PVP
Tryptamines	4-Methyl-αET αET αMT
Chemical classes	Substituted amphetamine Sub. benzofuran Sub. cathinone Sub. MDPEA Sub. PEA Sub. tryptamine

Clinical data

ATC code	None
Legal status
Legal status	BR: F2 CA: Schedule I DE: NpSG (Industrial and scientific use only) UK: Under Psychoactive Substances Act
Identifiers
IUPAC name 2-(pyrrolidin-1-yl)-1-(5,6,7,8-tetrahydronaphthalen-2-yl)pentan-1-one
CAS Number	2304915-07-7^Y
PubChem CID	132989549
ChemSpider	82954253
UNII	S5MU9GV87C
Chemical and physical data
Formula	C₁₉H₂₇NO
Molar mass	285.431 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCCC(C(=O)C1=CC2=C(CCCC2)C=C1)N3CCCC3
InChI InChI=1S/C19H27NO/c1-2-7-18(20-12-5-6-13-20)19(21)17-11-10-15-8-3-4-9-16(15)14-17/h10-11,14,18H,2-9,12-13H2,1H3 Key:MMIKQWIZKBYLKZ-UHFFFAOYSA-N

Th-Pvp

See also

References