Short description: Decongestants applied in nose
Topical decongestants are decongestants applied directly to the nasal cavity. Their effectiveness by themselves in the common cold appears to have a small benefit in adults.[1]
Topical decongestants should only be used by patients for a maximum of 5–7 days in a row, because rebound congestion may occur in the form of rhinitis medicamentosa. When used in adults for a short period of time side effects appear to be few.[1]
Mechanism of action
Topical decongestants are vasoconstrictors, and work by constricting the blood vessels within the nasal cavity.
Examples
- Ephedrine
- Levomethamphetamine
- Naphazoline
- Oxymetazoline
- Phenylephrine
- Pseudoephedrine
- Tramazoline
- Xylometazoline
See also
- Decongestant
- Nasal irrigation
- Nasal spray
References
- ↑ 1.0 1.1 Deckx, L; De Sutter, AI; Guo, L; Mir, NA; van Driel, ML (17 October 2016). "Nasal decongestants in monotherapy for the common cold.". The Cochrane Database of Systematic Reviews 10: CD009612. doi:10.1002/14651858.CD009612.pub2. PMID 27748955.
Decongestants and other nasal preparations (R01) |
|---|
| Topical | | Sympathomimetics, plain |
- Cyclopentamine
- Ephedrine
- Epinephrine
- Fenoxazoline
- Levomethamphetamine
- Metizoline
- Naphazoline
- Oxymetazoline
- Phenylephrine
- Propylhexedrine
- Tetryzoline
- Tramazoline
- Tuaminoheptane
- Tymazoline
- Xylometazoline
|
|---|
Antiallergic agents, excluding corticosteroids |
- histamine antagonists (Levocabastine
- Antazoline
- Thonzylamine)
- mast cell stabilizer (some are also antihistamines) (Cromoglicic acid
- Nedocromil
- Azelastine
- Olopatadine
- Lodoxamide)
|
|---|
| Corticosteroids |
- Beclometasone dipropionate
- Betamethasone#
- Budesonide
- Ciclesonide
- Dexamethasone
- Flunisolide
- Fluticasone (Fluticasone furoate, Fluticasone propionate)
- Mometasone furoate
- Prednisolone#
- Tixocortol
- Triamcinolone
- Triamcinolone acetonide
|
|---|
| Other nasal preparations |
- Cafaminol
- Calcium hexamine thiocyanate
- Eucalyptus oil
- Framycetin
- Hexamidine
- Hyaluronan
- Ipratropium bromide
- Mupirocin
- Retinol
- Ritiometan
- Saline water
|
|---|
|
|---|
Systemic use: Sympathomimetics |
- Phenylephrine
- Phenylpropanolamine
- Pseudoephedrine (+loratadine)
|
|---|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
 | Original source: https://en.wikipedia.org/wiki/Topical decongestant. Read more |