Short description: none
The glucocorticoid receptor.
The corticosteroid receptors are receptors for corticosteroids.[1] They include the following two nuclear receptors:[1][2][3]
- Glucocorticoid receptor (type I) – glucocorticoids like cortisol
- Mineralocorticoid receptor (type I) – mineralocorticoids like aldosterone
There are also membrane corticosteroid receptors, including the membrane glucocorticoid receptors and the membrane mineralocorticoid receptors, which are not well-characterized at present.[4][5][6]
References
- ↑ 1.0 1.1 Scott T. Brady; George J. Siegel; Robert Wayne Albers; Donald Lowell Price (2012). Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology. Academic Press. pp. 522–. ISBN 978-0-12-374947-5. https://books.google.com/books?id=NPqgM38h4LsC&pg=PA522.
- ↑ Eugenia Wang; D. Stephen Snyder (13 August 1998). Handbook of the Aging Brain. Academic Press. pp. 22–. ISBN 978-0-08-053322-3. https://books.google.com/books?id=KdQN6ERV33IC&pg=PA22.
- ↑ Hormones, Brain and Behavior, Five-Volume Set. Academic Press. 18 June 2002. pp. 267–. ISBN 978-0-08-053415-2. https://books.google.com/books?id=6GgHpQdk8vYC&pg=PA267.
- ↑ "Mineralocorticoid and glucocorticoid receptors at the neuronal membrane, regulators of nongenomic corticosteroid signalling". Mol. Cell. Endocrinol. 350 (2): 299–309. 2012. doi:10.1016/j.mce.2011.06.020. PMID 21736918.
- ↑ "Minireview: rapid glucocorticoid signaling via membrane-associated receptors". Endocrinology 147 (12): 5549–56. 2006. doi:10.1210/en.2006-0981. PMID 16946006.
- ↑ "Non-genomic actions of aldosterone: from receptors and signals to membrane targets". Mol. Cell. Endocrinol. 350 (2): 223–34. 2012. doi:10.1016/j.mce.2011.07.019. PMID 21801805. https://figshare.com/articles/journal_contribution/10787066.
Glucocorticoid receptor modulators |
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| GR | | Agonists |
- Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone
- 5α-Dihydrocorticosterone
- 9α-Fluorocortisone (alfluorone)
- 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
- 11-Dehydrocorticosterone acetate
- 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
- 11-Deoxycortisol (cortodoxone, cortexolone)
- Cortifen (cortiphen, kortifen)
- Cortodoxone acetate
- 21-Deoxycortisol
- Δ7-Prednisolone
- Δ7-Prednisolone 21-acetate
- Amebucort
- Chloroprednisone
- Cloprednol
- Corticosterone
- Corticosterone acetate
- Corticosterone benzoate
- Cortisol (hydrocortisone)
- Benzodrocortisone (hydrocortisone benzoate)
- Hydrocortamate (hydrocortisone diethylaminoacetate)
- Hydrocortisone esters
- Cortisone
- Deprodone
- Dichlorisone
- Dichlorisone acetate
- Dichlorisone diacetate
- Difluprednate
- Endrisone (endrysone)
- Etiprednol
- Etiprednol dicloacetate (etiprednol dichloroacetate)
- Fludrocortisone (fludrocortone)
- Fluorometholone
- Fluperolone
- Fluprednisolone
- Halopredone
- Halopredone acetate (halopredone diacetate)
- Isoflupredone (9α-fluoroprednisolone)
- Loteprednol
- Mazipredone (depersolone)
- Medrysone
- Methylprednisolone
- Methylprednisolone esters
- Prebediolone
- Prednisolone
- Prednazate
- Prednazoline
- Prednicarbate (prednisolone ethylcarbonate propionate)
- Prednimustine
- Prednisolamate (prednisolone diethylaminoacetate)
- Prednisolone esters
- Prednisone
- Pregnenolone
- Pregnenolone acetate
- Pregnenolone succinate (pregnenolone hemisuccinate)
- Resocortol
- Tipredane
- Tixocortol
- Butixocort (tixocortol butyrate)
- Tixocortol pivalate
- Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone
- Alclometasone
- Alclometasone dipropionate
- Amelometasone
- Beclometasone (beclomethasone)
- Betamethasone (betametasone)
- Betamethasone esters
- Cortobenzolone (betamethasone salicylate)
- Ciclometasone (ciclomethasone, cyclomethasone)
- Clobetasol
- Clobetasone
- Clocortolone
- Cloticasone
- Cormetasone (cormethasone)
- Descinolone
- Desoximetasone (desoxymethasone)
- Dexamethasone (dexametasone)
- Diflorasone
- Diflucortolone
- Diflucortolone pivalate
- Diflucortolone valerate
- Dimesone
- Doxibetasol (doxybetasol)
- Fluclorolone
- Flumetasone (flumethasone)
- Flumetasone acetate
- Flumetasone pivalate
- Fluocinolone
- Fluocortin
- Fluocortin butyl (fluocortin butylate)
- Fluocortolone
- Fluprednidene (fluprednylidene)
- Fluticasone
- Fluticasone furoate
- Fluticasone propionate
- Halocortolone
- Halometasone
- Icometasone
- Icometasone enbutate (icometasone butyrate acetate)
- Isoprednidene
- Locicortolone (locicortone)
- Locicortolone dicibate (locicortone dicibate)
- Meclorisone
- Meprednisone (methylprednisone)
- Meprednisone acetate
- Meprednisone hydrogen succinate (methylprednisone hemisuccinate)
- Mometasone
- Paramethasone
- Paramethasone acetate
- Paramethasone disodium phosphate
- Paramethasone phosphate
- Prednylidene
- Prednylidene diethylaminoacetate
- Rimexolone
- Ticabesone
- Timobesone
- Triamcinolone
- Ulobetasol (halobetasol)
- Vamorolone
- Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide)
- Amcinafal (triamcinolone pentanonide)
- Amcinafide (triamcinolone acetophenide)
- Amcinonide (triamcinolone acetate cyclopentanonide)
- Budesonide
- Ciclesonide
- Cicortonide
- Deflazacort (azacort)
- Descinolone acetonide
- Desonide (hydroxyprednisolone acetonide)
- Desonide disodium phosphate
- Desonide pivalate
- Dexbudesonide
- Drocinonide
- Fluazacort
- Fluclorolone acetonide (flucloronide)
- Fludroxycortide (flurandrenolone, flurandrenolide)
- Flumoxonide
- Flunisolide
- Fluocinolone acetonide
- Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate)
- Fluocinonide (fluocinolide, fluocinolone acetonide acetate)
- Procinonide (fluocinolone acetonide propionate)
- Formocortal
- Halcinonide
- Itrocinonide
- Rofleponide
- Tralonide
- Triamcinolone acetonide
- Flupamesone (triamcinolone acetonide metembonate)
- Triamcinolone acetonide esters
- Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB)
- Triclonide
- Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol
- Cortivazol
- Domoprednate
- Naflocort
- Nicocortonide
- Nivacortol (nivazol)
- Oxisopred
- RU-26988
- RU-28362
- Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate
- 17α-Hydroxyprogesterone
- Bromoketoprogesterone
- Chlormadinone acetate
- Cyproterone
- Cyproterone acetate
- Danazol
- Delmadinone acetate
- Desogestrel
- DU-41165
- Etonogestrel
- Flugestone
- Flugestone acetate (flurogestone acetate)
- Fluoromedroxyprogesterone acetate
- Fluoxymesterone
- Gestodene
- Medrogestone
- Medroxyprogesterone acetate
- Megestrol acetate
- Metribolone
- Norgestomet
- Osaterone acetate
- Progesterone
- Promegestone
- RU-2309
- Quingestrone
- Segesterone acetate (nestorone)
- Tetrahydrogestrinone
- Nonsteroidal glucocorticoids: AZD-5423
- GSK-9027
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Mixed (SEGRMs) |
- Dagrocorat
- Fosdagrocorat
- Mapracorat
|
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| Antagonists |
- 7α-Hydroxy-DHEA
- 17α-Methylprogesterone
- Aglepristone
- Asoprisnil
- Asoprisnil ecamate
- C108297
- C113176
- CORT-108297
- Cyproterone acetate
- Exicorilant (CORT-125281)
- Guggulsterone
- Ketoconazole
- Lilopristone
- LLY-2707
- Metapristone (RU-42633)
- Miconazole
- Mifepristone (RU-486)
- Miricorilant (CORT-118335)
- Onapristone
- ORG-34116
- ORG-34517 (SCH-900636)
- ORG-34850
- Pregnenolone 16α-carbonitrile
- Relacorilant (CORT-125134)
- RTI 3021–012
- RTI 3021–022
- Telapristone
- Tibolone
- Toripristone
- Ulipristal acetate
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| Others |
- Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115)
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- See also
- Receptor/signaling modulators
- Glucocorticoids and antiglucocorticoids
- Mineralocorticoid receptor modulators
- List of corticosteroids
|
Mineralocorticoid receptor modulators |
|---|
| MR | | Agonists |
- 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
- 11-Dehydrocorticosterone acetate
- 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)
- 11-Deoxycortisol (cortodoxone, cortexolone)
- Cortifen (cortiphen, kortifen)
- Cortodoxone acetate
- 11β-Hydroxyprogesterone
- 16α,18-Dihydroxy-11-deoxycorticosterone
- 17α-Hydroxyaldosterone
- 18-Hydroxy-11-deoxycorticosterone
- 19-Norprogesterone
- Aldosterone
- Corticosterone
- Corticosterone acetate
- Corticosterone benzoate
- Cortisol (hydrocortisone)
- Benzodrocortisone (hydrocortisone benzoate)
- Hydrocortamate (hydrocortisone diethylaminoacetate)
- Hydrocortisone esters
- Cortisone
- Fludrocortisone (fludrocortone)
- Mometasone
- Prednisolone
- Prednazate
- Prednazoline
- Prednicarbate (prednisolone ethylcarbonate propionate)
- Prednimustine
- Prednisolamate (prednisolone diethylaminoacetate)
- Prednisolone esters
- Prednisone
|
|---|
| Antagonists |
- Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone
- 7α-Acetylthio-17α-hydroxyprogesterone
- 7α-Thiomethylspironolactone (SC-26519)
- 7α-Thioprogesterone (SC-8365)
- 7α-Thiospironolactone (SC-24813)
- 16α-Hydroxyprogesterone
- 17α-Hydroxyprogesterone (hydroxyprogesterone)
- 18-Deoxyaldosterone
- 18,19-Dinorprogesterone
- Canrenoate potassium (potassium canrenoate)
- Canrenoic acid (canrenoate)
- Canrenone (canrenoate y-lactone)
- Dicirenone
- Dimethisterone
- Drospirenone
- Dydrogesterone
- Eplerenone
- Gestodene
- Guggulsterone
- Hydroxyprogesterone caproate
- Medrogestone
- Mespirenone
- Metribolone
- Mexrenoate potassium
- Mexrenoic acid (mexrenoate)
- Mexrenone
- Oxprenoic acid (oxprenoate)
- Oxprenoate potassium (RU-28318)
- Pregnenolone
- Progesterone
- Prorenoate potassium
- Prorenoic acid (prorenoate)
- Prorenone
- RO-14-9012
- RU-26752
- SC-5233 (spirolactone)
- SC-8109
- SC-11927 (CS-1)
- SC-19886
- SC-27169
- Spirorenone
- Spironolactone
- Spiroxasone
- Tibolone
- Trimegestone
- ZK-91587
- ZK-97894
- Nonsteroidal: Amlodipine
- Apararenone
- Benidipine
- BR-4628
- Esaxerenone
- Felodipine
- Finerenone
- Miricorilant (CORT-118335)
- Nifedipine
- Nimodipine
- Nitrendipine
- PF-03882845
- SM-368229
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|
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- See also
- Receptor/signaling modulators
- Mineralocorticoids and antimineralocorticoids
- Glucocorticoid receptor modulators
- List of corticosteroids
|
 | Original source: https://en.wikipedia.org/wiki/Corticosteroid receptor. Read more |