Benexate

Benexate
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	none;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name Phenylmethyl 2-[4-[(diaminomethylideneamino)methyl]cyclohexanecarbonyl]oxybenzoate;
CAS Number	78718-52-2;
PubChem CID	2316;
ChemSpider	2226 ;
UNII	O3PR2X907M;
ChEMBL	ChEMBLCHEMBL2104696;
Chemical and physical data
Formula	C23H27N3O4
Molar mass	409.486 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCc1ccccc1)c3ccccc3OC(=O)C2CCC(C/N=C(\N)N)CC2;
	InChI InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26) ; Key:IAXUQWSLRKIRFR-UHFFFAOYSA-N ;
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Short description: Chemical compound

Benexate (BEX) is an anti-ulcer agent used in the treatment of acid-related disorders. It is unique in its inability to form salts that are both non-bitter and soluble.^[1]^[2]

Medical uses

Benexate is approved from treatment of gastric ulcer in Japan.^[3]

Mechanism of action

The mechanism of action of benexate involves promotion of prostaglandin synthesis, protein secretion, and blood flow stimulation in the gastrointestinal tract.^[4]

References

↑ "Differential effect of benexate hydrochloride betadex on prostaglandin levels in stomach and inflammatory sites in rats". Japanese Journal of Pharmacology 72 (2): 183–190. 1996. doi:10.1254/jjp.72.183. PMID 8912919.
↑ "Studies of benexate CD: effect of inclusion compound formation on the antiulcer activity of benexate, the effective ingredient of benexate CD.". Folia Pharmacologica Japonica (91): 377–383. 1998.
↑ "Benexate". Inxight Drugs. National Center for Advancing Translational Sciences. https://drugs.ncats.io/drug/O3PR2X907M.
↑ "Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers". Experimental and Therapeutic Medicine 12 (2): 573–580. 2016. doi:10.3892/etm.2016.3384. PMID 27446246.

Benexate

Contents

Medical uses

Mechanism of action

See also

References

Further reading

Clinical data

AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name Phenylmethyl 2-[4-[(diaminomethylideneamino)methyl]cyclohexanecarbonyl]oxybenzoate
CAS Number	78718-52-2
PubChem CID	2316
ChemSpider	2226^Y
UNII	O3PR2X907M
ChEMBL	ChEMBLCHEMBL2104696
Chemical and physical data
Formula	C₂₃H₂₇N₃O₄
Molar mass	409.486 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(OCc1ccccc1)c3ccccc3OC(=O)C2CCC(C/N=C(\N)N)CC2
InChI InChI=1S/C23H27N3O4/c24-23(25)26-14-16-10-12-18(13-11-16)21(27)30-20-9-5-4-8-19(20)22(28)29-15-17-6-2-1-3-7-17/h1-9,16,18H,10-15H2,(H4,24,25,26)^Y Key:IAXUQWSLRKIRFR-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)