Thiophene-2-Carboxaldehyde

Thiophene-2-carboxaldehyde

Names
Preferred IUPAC name Thiophene-2-carbaldehyde
Other names 2-formylthiophene, thiophene-2-aldehyde, T2A, 2-thiophenecarboxaldehyde
Identifiers
CAS Number	98-03-3
3D model (JSmol)	Interactive image
ChEBI	CHEBI:87301
ChEMBL	ChEMBL328441
ChemSpider	7086
EC Number	202-629-8
PubChem CID	7364
UNII	IW05BB9XBM
InChI InChI=1S/C5H4OS/c6-4-5-2-1-3-7-5/h1-4H Key: CNUDBTRUORMMPA-UHFFFAOYSA-N
SMILES C1=CSC(=C1)C=O
Properties
Chemical formula	C5H4OS
Molar mass	112.15 g·mol−1
Appearance	colorless liquid
Density	1.2 g/mL
Boiling point	198 °C (388 °F; 471 K)
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302, H315, H317, H319, H335
GHS precautionary statements	P261, P264, P270, P271, P272, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P333+313, P337+313, P362, P363, P403+233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Thiophene-2-carboxaldehyde is an organosulfur compound with the formula C₄H₃SCHO. It is one of two isomeric thiophenecarboxaldehydes. It is a colorless liquid that often appears amber after storage. It is versatile precursor to many drugs including eprosartan, Azosemide, and Teniposide.

Preparation

It can be prepared from thiophene by the Vilsmeier reaction.^[1] Alternatively, it is prepared from chloromethylation of thiophene.^[2]

References

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