Trib3

From Handwiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Tribbles homolog 3 is a protein that in humans is encoded by the TRIB3 gene.[1][2][3]

Function

The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. It is a pseudoenzyme that is thought to be a negative regulator of NF-kappaB, and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein has been reported to negatively regulate the cell survival serine-threonine kinase AKT1.[3] TRIB3 has recently been associated with neuronal signalling, and like TRIB1 and TRIB2, could be considered as a potential allosteric drug target [4][5]

Interactions

TRIB3 has been shown to interact with:

  • AKT1,[1]
  • CSNK2B,[6]
  • Fibronectin[6]
  • MCM3AP,[7]
  • RELA,[8]
  • SIAH1,[6] and
  • TIAF1.[6]

References

  1. ↑ 1.0 1.1 "TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver". Science 300 (5625): 1574–7. Jun 2003. doi:10.1126/science.1079817. PMID 12791994. Bibcode: 2003Sci...300.1574D. 
  2. ↑ "Tribbles: novel regulators of cell function; evolutionary aspects". Cell Mol Life Sci 63 (14): 1632–41. Aug 2006. doi:10.1007/s00018-006-6007-9. PMID 16715410. 
  3. ↑ 3.0 3.1 "Entrez Gene: TRIB3 tribbles homolog 3 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57761. 
  4. ↑ "Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease.". Trends in Cell Biology 27 (9): S0962-8924(16)30178-7. 2016. doi:10.1016/j.tcb.2016.11.002. PMID 27908682. 
  5. ↑ "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?". Biochemical Society Transactions 43 (5): 1095–1103. 2015. doi:10.1042/BST20150109. PMID 26517930. 
  6. ↑ 6.0 6.1 6.2 6.3 "E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3". Cell. Signal. 20 (5): 942–8. May 2008. doi:10.1016/j.cellsig.2008.01.010. PMID 18276110. 
  7. ↑ "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia". Oncogene 22 (18): 2823–35. May 2003. doi:10.1038/sj.onc.1206367. PMID 12743605. 
  8. ↑ "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription". J. Biol. Chem. 278 (29): 27072–9. July 2003. doi:10.1074/jbc.M209814200. PMID 12736262. 

Further reading

  • "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D. 
  • "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
  • "SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription.". J. Biol. Chem. 278 (29): 27072–9. 2003. doi:10.1074/jbc.M209814200. PMID 12736262. 
  • "SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in human tumors and is regulated by hypoxia.". Oncogene 22 (18): 2823–35. 2003. doi:10.1038/sj.onc.1206367. PMID 12743605. 
  • "Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription.". Biochem. Biophys. Res. Commun. 309 (4): 774–8. 2003. doi:10.1016/j.bbrc.2003.08.069. PMID 13679039. 
  • "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
  • "Human tribbles, a protein family controlling mitogen-activated protein kinase cascades.". J. Biol. Chem. 279 (41): 42703–8. 2004. doi:10.1074/jbc.M407732200. PMID 15299019. 
  • "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
  • "TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.". EMBO J. 24 (6): 1243–55. 2005. doi:10.1038/sj.emboj.7600596. PMID 15775988. 
  • "Characterization of human NIPK (TRB3, SKIP3) gene activation in stressful conditions.". Biochem. Biophys. Res. Commun. 330 (1): 210–8. 2005. doi:10.1016/j.bbrc.2005.02.149. PMID 15781252. 
  • "The functional Q84R polymorphism of mammalian Tribbles homolog TRB3 is associated with insulin resistance and related cardiovascular risk in Caucasians from Italy.". Diabetes 54 (9): 2807–11. 2005. doi:10.2337/diabetes.54.9.2807. PMID 16123373. 
  • "TRB3 is a PI 3-kinase dependent indicator for nutrient starvation.". Cell. Signal. 18 (6): 899–909. 2006. doi:10.1016/j.cellsig.2005.08.002. PMID 16129579. 
  • "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • "Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity.". J. Biol. Chem. 281 (40): 29719–29. 2006. doi:10.1074/jbc.M511636200. PMID 16887816. 
  • "Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3.". Mol. Cell. Biol. 26 (22): 8217–27. 2007. doi:10.1128/MCB.00979-06. PMID 16966378. 




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