Chloride Channel Blocker

From Handwiki

A chloride channel blocker is a type of drug which inhibits the transmission of ions (Cl−) through chloride channels. Niflumic acid is a chloride channel blocker that has been used in experimental scientific research.[1] Another example is anthracene-9-carboxylic acid, a potent blocker of the CLCN1-type chloride channel found in skeletal muscle, which is used to study animal models of myotonia congenita.[2]

See also

  • Chloride channel opener

References

  1. ↑ Knauf, P. A. (1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMID 6736917. 
  2. ↑ Villegas-Navarro, A.; Martinez-Morales, M.; Morales-Aguilera, A. (1986). "Pharmacokinetics of anthracene-9-carboxylic acid, a potent myotonia-inducer". Archives Internationales de Pharmacodynamie et de Therapie 280 (1): 5–21. PMID 3718080. 

Further reading

  • Phillis, J.W; Song, D.; O'Regan, M.H (1998). "Tamoxifen, a chloride channel blocker, reduces glutamate and aspartate release from the ischemic cerebral cortex". Brain Research 780 (2): 352–5. doi:10.1016/S0006-8993(97)01352-8. PMID 9507191. 
  • Zhou, Yuhong; Shapiro, Michael; Dong, Qu; Louahed, Jamila; Weiss, Christine; Wan, Shanhong; Chen, Qiming; Dragwa, Carl et al. (2008). "A Calcium-Activated Chloride Channel Blocker Inhibits Goblet Cell Metaplasia and Mucus Overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. pp. 150–170. doi:10.1002/0470860790.ch10. ISBN 9780470844786. https://books.google.com/books?id=yflNeSF5XygC&pg=PA150. 
  • Mohamed, Fahim; Senarathna, Lalith; Percy, Adrian; Abeyewardene, Manel; Eaglesham, Geoffrey; Cheng, Ron; Azher, Shifa; Hittarage, Ariyasena et al. (2004). "Acute Human Self‐Poisoning with theN‐Phenylpyrazole Insecticide Fipronil—a GABAA‐Gated Chloride Channel Blocker". Journal of Toxicology: Clinical Toxicology 42 (7): 955–63. doi:10.1081/CLT-200041784. PMID 15641641. 
  • Lukacs, Gergely L.; Nanda, Arvind; Rotstein, Ori D.; Grinstein, Sergio (1991). "The chloride channel blocker 5-nitro-2-(3-phenylpropyl-amino) benzoic acid (NPPB) uncouples mitochondria and increases the proton permeability of the plasma membrane in phagocytic cells". FEBS Letters 288 (1–2): 17–20. doi:10.1016/0014-5793(91)80992-C. PMID 1652470. 
  • Kang, J. X.; Man, S. F.; Brown, N. E.; Labrecque, P. A.; Clandinin, M. T. (1992). "The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells". Biochemical Journal 285 (3): 725–9. doi:10.1042/bj2850725. PMID 1323271. 
  • Liu, J.; Lai, Z. F.; Wang, X. D.; Tokutomi, N.; Nishi, K. (1998). "Inhibition of Sodium Current by Chloride Channel Blocker 4,4′-Diisothiocyanatostilbene-2,2′-Disulfonic Acid (DIDS) in Guinea Pig Cardiac Ventricular Cells". Journal of Cardiovascular Pharmacology 31 (4): 558–67. PMID 9554805. http://insights.ovid.com/pubmed?pmid=9554805. 




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