Nonsteroidal

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A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative.[1][2] Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.[3]

List of nonsteroidal steroid receptor modulators

Examples include the following:[1][2]

  • Estrogens: benzestrol, bifluranol, estrobin (DBE), diethylstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens
  • SERMs: acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, tamoxifen, toremifene, trioxifene, zindoxifene, zuclomifene
  • Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, inocoterone acetate, nilutamide, RU-58642, RU-58841, and topilutamide
  • SARMs: AC-262,356, acetothiolutamide, andarine, BMS-564,929, enobosarm (ostarine), LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503
  • Aromatase inhibitors: anastrozole, aminoglutethimide, fadrozole, finrozole, letrozole, liarozole, norendoxifen, rogletimide (pyridoglutethimide), vorozole
  • Other steroidogenesis inhibitors: aminoglutethimide, ketoconazole, orteronel, seviteronel, others
  • Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), esaxerenone (antimineralocorticoid), apararenone (antimineralocorticoid), AZD5423 (glucocorticoid), mapracorat (SGRM)

See also

  • Nonsteroidal antiandrogen
  • Nonsteroidal estrogen

References

  1. ↑ 1.0 1.1 Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business Media. pp. 166–. ISBN 978-1-4612-4096-9. https://books.google.com/books?id=LAnpBwAAQBAJ&pg=PA166. 
  2. ↑ 2.0 2.1 Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus); Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University (27 July 2005). Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. Oxford University Press, USA. pp. 322–. ISBN 978-0-19-802645-7. https://books.google.com/books?id=UnKa7zARGV0C&pg=PA322. 
  3. ↑ "Origins and impact of the term 'NSAID'". Inflammopharmacology 22 (5): 263–7. Oct 2014. doi:10.1007/s10787-014-0211-2. PMID 25064056. https://www.researchgate.net/publication/264248818. 

Further reading

  • "A chemical classification of nonsteroidal antagonists of sex-steroid hormone action". J. Steroid Biochem. 31 (4B): 525–44. 1988. doi:10.1016/0022-4731(88)90004-0. PMID 3059055. 
  • Buijsman, Rogier; Hermkens, Pedro; Rijn, Rachel; Stock, H.; Teerhuis, N. (2005). "Non-Steroidal Steroid Receptor Modulators". Current Medicinal Chemistry 12 (9): 1017–1075. doi:10.2174/0929867053764671. ISSN 0929-8673. PMID 16821162. 
  • "Non-steroidal steroid receptor modulators". IDrugs 9 (7): 488–94. 2006. doi:10.2174/0929867053764671. PMID 16821162. 




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