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1. Rho kinase inhibitor: Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular ... (Chemistry) [100%] 2023-12-14 [Protein kinase inhibitors]
2. Tyrosine kinase inhibitor: A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. (Chemistry) [100%] 2023-12-14 [Tyrosine kinase inhibitors]
3. Protein kinase inhibitor: A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its ... (Chemistry) [100%] 2023-12-16 [Protein kinase inhibitors]
4. Phosphoinositide 3-kinase inhibitor: Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K ... [86%] 2023-12-14 [Experimental cancer drugs] [Phosphoinositide 3-kinase inhibitors]...
5. Phosphoinositide 3-kinase inhibitor: Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K ... (Chemistry) [86%] 2023-12-14 [Experimental cancer drugs]
6. Raf kinase inhibitor protein: The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2 ... [86%] 2023-12-14 [Protein kinase inhibitors]
7. Kinase tyrosine-based inhibitory motif: The term Kinase tyrosine-based inhibitory motif (KTIM) was coined by a group of immunology researchers from McGill University, Montreal, Quebec, Canada in 2008 to represent any immunoreceptor tyrosine-based inhibitory-like sequence motif, with the consensus sequence I/V ... (Type of motif in immunology) [77%] 2024-02-04 [Immunology]
8. Bcr-Abl tyrosine-kinase inhibitor: Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called ... (Medicine) [77%] 2023-12-14 [Medical treatments]
9. Cyclin-dependent kinase inhibitor 1C: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes ... [77%] 2023-12-14 [Cell cycle] [Tumor suppressor genes]...
10. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Biology) [77%] 2023-12-14 [Protein domains]
11. Cyclin-dependent kinase inhibitor 1C: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes ... (Biology) [77%] 2023-12-14 [Cell cycle] [Tumor suppressor genes]...
12. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Protein which inhibits cyclin-dependent kinase) [77%] 2024-09-06 [Protein domains]
13. Kinare Kinare: Kinare Kinare (transl. Along the shore) is a 1963 Indian Hindi-language film directed by Chetan Anand, who also plays a pivotal role. [76%] 2023-12-17 [1963 films] [1960s Hindi-language films]...
14. Inheritors (play): Inheritors is a four-act play written by the American dramatist Susan Glaspell, first performed in 1921 (103 years ago) (1921). The play concerns the legacy of an idealistic farmer who wills his highly coveted midwest farmland to the establishment ... (Play) [73%] 2024-01-01 [1921 plays] [Plays by Susan Glaspell]...
15. PCSK9 inhibitors: PCSK9 inhibitors are a class of medications used to treat hypercholesterolemia. In those on high doses of statins, they decrease risk of further problems by 1.5% over 2.5 years. [64%] 2024-01-01
16. PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... (Chemistry) [64%] 2023-12-17 [Protein kinase inhibitors]
17. PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... [64%] 2024-02-11 [Protein kinase inhibitors]
18. Lipase inhibitors: Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. [64%] 2023-12-19 [Lipase inhibitors] [Obesity]...
19. Protease inhibitors: Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to ... [64%] 2023-10-09 [Antivirals] [Antiretroviral drugs]...
20. Phosphodiesterase inhibitors: Articles Most recent articles on Phosphodiesterase inhibitors Most cited articles on Phosphodiesterase inhibitors Review articles on Phosphodiesterase inhibitors Articles on Phosphodiesterase inhibitors in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Phosphodiesterase inhibitors Images of Phosphodiesterase inhibitors Photos ... [64%] 2023-12-20 [Phosphodiesterase inhibitors] [Drugs]...