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1. HIF prolyl-hydroxylase inhibitor: Not to be confused with Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors Hypoxia-inducible factor prolyl hydroxylase Inhibitors (HIF-PHIs) also known as hypoxia-inducible factor stabilizers (HIF stabilizers) are a novel class of drugs that act by inhibiting hypoxia-inducible ... (Chemistry) [100%] 2023-11-29 [Enzyme inhibitors]
2. Factor Inhibiting HIF Asparaginyl Hydroxylase Inhibitors: Factor Inhibiting HIF (FIH) Asparaginyl Hydroxylase Inhibitors inhibit the FIH pathway also catalyzed by Asparaginyl Hydroxylase inhibition. Before 2010s thought to be identical to HIF prolyl-hydroxylase pathway, studies have shown FIH to be the master regulator (relative to HIF ... (Chemistry) [86%] 2023-03-02 [Enzyme inhibitors]
3. Hydrolase: Articles Most recent articles on Hydrolase Most cited articles on Hydrolase Review articles on Hydrolase Articles on Hydrolase in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Hydrolase Images of Hydrolase Photos of Hydrolase Podcasts & MP3s on Hydrolase ... [85%] 2023-03-29 [Hydrolases]
4. Hydrolase: Articles Most recent articles on Hydrolase Most cited articles on Hydrolase Review articles on Hydrolase Articles on Hydrolase in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Hydrolase Images of Hydrolase Photos of Hydrolase Podcasts & MP3s on Hydrolase ... [85%] 2024-01-21 [Hydrolases]
5. Inheritors (play): Inheritors is a four-act play written by the American dramatist Susan Glaspell, first performed in 1921 (103 years ago) (1921). The play concerns the legacy of an idealistic farmer who wills his highly coveted midwest farmland to the establishment ... (Play) [81%] 2024-01-01 [1921 plays] [Plays by Susan Glaspell]...
6. Vinorine hydroxylase: In enzymology, a vinorine hydroxylase (EC 1.14.14.104, Formerly EC 1.14.13.75) is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are vinorine, NADPH, H, and O2, whereas its 3 products ... (Biology) [77%] 2023-09-04 [EC 1.14.14] [NADPH-dependent enzymes]...
7. Tryptophan hydroxylase: Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. (Class of enzymes) [77%] 2023-07-27 [EC 1.14.16]
8. Vinorine hydroxylase: In enzymology, a vinorine hydroxylase (EC 1.14.14.104, Formerly EC 1.14.13.75) is an enzyme that catalyzes the chemical reaction The 4 substrates of this enzyme are vinorine, NADPH, H, and O2, whereas its 3 products ... [77%] 2023-10-18 [EC 1.14.14] [NADPH-dependent enzymes]...
9. 21-Hydroxylase: Steroid 21-hydroxylase is a protein that in humans is encoded by the CYP21A2 gene. The protein is an enzyme that hydroxylates steroids at the C21 position on the molecule. (Human enzyme that hydroxylates steroids) [77%] 2023-12-03 [Enzymes] [EC 1.14.99]...
10. Tryptophan hydroxylase: Tryptophan hydroxylase (TPH) is an enzyme (EC 1.14.16.4) involved in the synthesis of the neurotransmitter serotonin. Tyrosine hydroxylase, phenylalanine hydroxylase, and tryptophan hydroxylase together constitute the family of biopterin-dependent aromatic amino acid hydroxylases. [77%] 2023-04-27 [EC 1.14.16]
11. Tyrosine hydroxylase: Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen (O2), as well as iron (Fe) and ... (Biology) [77%] 2024-04-21 [EC 1.14.16]
12. PCSK9 inhibitors: PCSK9 inhibitors are a class of medications used to treat hypercholesterolemia. In those on high doses of statins, they decrease risk of further problems by 1.5% over 2.5 years. [72%] 2024-01-01
13. PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... (Chemistry) [72%] 2023-12-17 [Protein kinase inhibitors]
14. PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... [72%] 2024-02-11 [Protein kinase inhibitors]
15. Lipase inhibitors: Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. [72%] 2023-12-19 [Lipase inhibitors] [Obesity]...
16. Protease inhibitors: Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to ... [72%] 2023-10-09 [Antivirals] [Antiretroviral drugs]...
17. Phosphodiesterase inhibitors: Articles Most recent articles on Phosphodiesterase inhibitors Most cited articles on Phosphodiesterase inhibitors Review articles on Phosphodiesterase inhibitors Articles on Phosphodiesterase inhibitors in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Phosphodiesterase inhibitors Images of Phosphodiesterase inhibitors Photos ... [72%] 2023-12-20 [Phosphodiesterase inhibitors] [Drugs]...
18. STAT inhibitors: STAT inhibitors are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of cytoplasmic induction factors. Inhibitors of STAT proteins are being developed for use in cancer therapy. (Chemistry) [72%] 2023-12-15 [Enzyme inhibitors]
19. Angiokinase inhibitors: Angiokinase inhibitors are a new therapeutic target for the management of cancer. They inhibit tumour angiogenesis, one of the key processes leading to invasion and metastasis of solid tumours, by targeting receptor tyrosine kinases. (Chemistry) [72%] 2023-12-16 [Tyrosine kinase inhibitors]
20. Angiokinase inhibitors: Angiokinase inhibitors are a new therapeutic target for the management of cancer. They inhibit tumour angiogenesis, one of the key processes leading to invasion and metastasis of solid tumours, by targeting receptor tyrosine kinases. [72%] 2023-12-20 [Tyrosine kinase inhibitors]