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1. Rho kinase inhibitor: Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular ... (Chemistry) [100%] 2023-12-14 [Protein kinase inhibitors]
2. Tyrosine kinase inhibitor: A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. (Chemistry) [100%] 2023-12-14 [Tyrosine kinase inhibitors]
3. Protein kinase inhibitor: A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its ... (Chemistry) [100%] 2023-12-16 [Protein kinase inhibitors]
4. Phosphoinositide 3-kinase inhibitor: Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K ... [86%] 2023-12-14 [Experimental cancer drugs] [Phosphoinositide 3-kinase inhibitors]...
5. Phosphoinositide 3-kinase inhibitor: Phosphoinositide 3-kinase inhibitors (PI3K inhibitors) are a class of medical drugs that are mainly used to treat advanced cancers. They function by inhibiting one or more of the phosphoinositide 3-kinase (PI3K) enzymes, which are part of the PI3K ... (Chemistry) [86%] 2023-12-14 [Experimental cancer drugs]
6. Raf kinase inhibitor protein: The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2 ... [86%] 2023-12-14 [Protein kinase inhibitors]
7. Kinase tyrosine-based inhibitory motif: The term Kinase tyrosine-based inhibitory motif (KTIM) was coined by a group of immunology researchers from McGill University, Montreal, Quebec, Canada in 2008 to represent any immunoreceptor tyrosine-based inhibitory-like sequence motif, with the consensus sequence I/V ... (Type of motif in immunology) [77%] 2024-02-04 [Immunology]
8. Bcr-Abl tyrosine-kinase inhibitor: Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called ... (Medicine) [77%] 2023-12-14 [Medical treatments]
9. Cyclin-dependent kinase inhibitor 1C: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes ... [77%] 2023-12-14 [Cell cycle] [Tumor suppressor genes]...
10. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Biology) [77%] 2023-12-14 [Protein domains]
11. Cyclin-dependent kinase inhibitor 1C: Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is a protein which in humans is encoded by the CDKN1C imprinted gene. Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes ... (Biology) [77%] 2023-12-14 [Cell cycle] [Tumor suppressor genes]...
12. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Protein which inhibits cyclin-dependent kinase) [77%] 2024-09-06 [Protein domains]
13. Kinare Kinare: Kinare Kinare (transl. Along the shore) is a 1963 Indian Hindi-language film directed by Chetan Anand, who also plays a pivotal role. [76%] 2023-12-17 [1963 films] [1960s Hindi-language films]...
14. Inheritors (play): Inheritors is a four-act play written by the American dramatist Susan Glaspell, first performed in 1921 (103 years ago) (1921). The play concerns the legacy of an idealistic farmer who wills his highly coveted midwest farmland to the establishment ... (Play) [73%] 2024-01-01 [1921 plays] [Plays by Susan Glaspell]...
15. Glucosamine kinase: In enzymology, a glucosamine kinase (EC 2.7.1.8) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and D-glucosamine, whereas its two products are ADP and D-glucosamine phosphate ... (Biology) [64%] 2022-12-02 [EC 2.7.1] [Enzymes of unknown structure]...
16. Creatine kinase: Articles Most recent articles on Creatine kinase Most cited articles on Creatine kinase Review articles on Creatine kinase Articles on Creatine kinase in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Creatine kinase Images of Creatine kinase Photos ... [64%] 2023-04-07 [Chemical pathology] [EC 2.7.3]...
17. Ethanolamine kinase: In enzymology, an ethanolamine kinase (EC 2.7.1.82) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and ethanolamine, whereas its two products are ADP and O-phosphoethanolamine. This enzyme ... [64%] 2023-12-14 [EC 2.7.1] [Enzymes of unknown structure]...
18. Deoxyguanosine kinase: In enzymology, a deoxyguanosine kinase (EC 2.7.1.113) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and deoxyguanosine, whereas its two products are ADP and dGMP. This enzyme belongs ... [64%] 2023-12-17 [EC 2.7.1] [Enzymes of known structure]...
19. Diacylglycerol kinase: Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low, allowing DAG to ... [64%] 2022-11-13 [Integral membrane proteins] [EC 2.7.1]...
20. Protein kinase: A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ... (Enzyme that adds phosphate groups to other proteins) [64%] 2024-01-26 [EC 2.7] [Protein kinases]...