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1. Protein kinase inhibitor: A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its ... (Chemistry) [100%] 2023-12-16 [Protein kinase inhibitors]
2. Raf kinase inhibitor protein: The Raf kinase inhibitor protein (RKIP) is a kinase inhibitor protein, that regulates many signaling pathways within the cell. RKIP is a member of the phosphatidylethanolamine-binding protein family and has displayed disruptive regulation on the Raf-1-MEK1/2 ... [86%] 2023-12-14 [Protein kinase inhibitors]
3. Protein kinase: A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ... (Enzyme that adds phosphate groups to other proteins) [82%] 2024-01-26 [EC 2.7] [Protein kinases]...
4. Protein kinase: In biochemistry, protein kinases are "a family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein." In signal transduction, cell surface receptors may activate second messenger systems such as adenyl cyclase-cyclic AMP ... [82%] 2023-06-11
5. Protein kinase: A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules. Phosphorylation usually results in a functional change of the target protein ... (Enzyme that adds phosphate groups to other proteins) [82%] 2023-12-14 [EC 2.7] [Protein kinases]...
6. Inhibitor protein: The inhibitor protein (IP) is situated in the mitochondrial matrix and protects the cell against rapid ATP hydrolysis during momentary ischaemia. In oxygen absence, the pH of the matrix drops. (Cell biology) [77%] 2023-10-23 [Cell biology]
7. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Biology) [77%] 2023-12-14 [Protein domains]
8. Cyclin-dependent kinase inhibitor protein: A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein that inhibits the enzyme cyclin-dependent kinase (CDK) and Cyclin activity by stopping the cell cycle if there are unfavorable conditions, therefore, acting as ... (Protein which inhibits cyclin-dependent kinase) [77%] 2024-09-06 [Protein domains]
9. Rho kinase inhibitor: Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular ... (Chemistry) [69%] 2023-12-14 [Protein kinase inhibitors]
10. Tyrosine kinase inhibitor: A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. (Chemistry) [69%] 2023-12-14 [Tyrosine kinase inhibitors]
11. Protein kinase D1: Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene. Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. [67%] 2023-03-08 [EC 2.7.11]
12. Tau-protein kinase: In enzymology, a tau-protein kinase (EC 2.7.11.26) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and tau protein, whereas its two products are ADP and O-phospho ... (Class of enzymes) [67%] 2022-02-24 [EC 2.7.11] [Enzymes of known structure]...
13. Protein kinase Mζ: Protein kinase Mζ (also called PKMζ or PKMzeta) is the independent catalytic domain of protein kinase Cζ and, lacking an autoinhibitory regulatory domain of the full-length PKCζ, is constitutively active. This constitutive or autonomous activity allows the kinase to be independent of second ... [67%] 2023-05-14
14. Protein kinase N1: Serine/threonine-protein kinase N1 is an enzyme that in humans is encoded by the PKN1 gene. The protein encoded by this gene belongs to the protein kinase C superfamily. (Protein-coding gene in the species Homo sapiens) [67%] 2022-06-21 [EC 2.7.11]
15. Protein kinase B: Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration. Akt1 is involved in cellular ... [67%] 2023-08-05 [EC 2.7.11] [Protein kinases]...
16. Myotonin-protein kinase: Myotonin-protein kinase (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase (DMK) is an enzyme that in humans is encoded by the DMPK gene. The dmpk gene product is a Ser/Thr protein ... [67%] 2023-05-22 [EC 2.7.11] [Human proteins]...
17. Protein kinase domain: The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. [67%] 2022-12-27 [Protein domains] [Peripheral membrane proteins]...
18. Tau-protein kinase: In enzymology, a tau-protein kinase (EC 2.7.11.26) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are ATP and tau protein, whereas its two products are ADP and O-phospho ... (Biology) [67%] 2023-01-07 [EC 2.7.11] [Enzymes of known structure]...
19. Myotonin-protein kinase: Myotonin-protein kinase (MT-PK) also known as myotonic dystrophy protein kinase (MDPK) or dystrophia myotonica protein kinase (DMPK) is an enzyme that in humans is encoded by the DMPK gene. The dmpk gene product is a Ser/Thr protein ... (Biology) [67%] 2024-05-09 [EC 2.7.11] [Human proteins]...
20. Protein kinase A: In cell biology, protein kinase A (PKA) is a family of serine-threonine kinases whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase (EC 2.7.11.11). (Family of enzymes) [67%] 2025-06-10 [Signal transduction] [Protein kinases]...