Isopropyl Myristate

Isopropyl myristate^[1]
Names
	Preferred IUPAC name Propan-2-yl tetradecanoate
	Other names Tetradecanoic acid, 1-methylethyl ester; Myristic acid isopropyl ester
Identifiers
CAS Number	110-27-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL207602;
ChemSpider	7751 ;
EC Number	203-751-4;
KEGG	D02296 ;
MeSH	C008205
PubChem CID	8042;
RTECS number	XB8600000;
UNII	0RE8K4LNJS ;
	InChI InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 Key: AXISYYRBXTVTFY-UHFFFAOYSA-N ; InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 Key: AXISYYRBXTVTFY-UHFFFAOYAN;
	SMILES CCCCCCCCCCCCCC(=O)OC(C)C;
Properties
Chemical formula	C17H34O2
Molar mass	270.457 g·mol−1
Density	0.85 g/cm3
Boiling point	167 °C (333 °F; 440 K) at 9 mmHg
Hazards
NFPA 704 (fire diamond)	1 0 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid.

Uses

Isopropyl myristate is a polar emollient and is used in cosmetic and topical pharmaceutical preparations where skin absorption is desired. It is also used as a treatment for head lice.^[2] It is also in flea and tick killing products for pets.

It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.

Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid is theorized to be responsible for decreasing of the pH value of formulations.^[3]^[4]

References

↑ MSDS for isopropyl myristate
↑ Anti-Lice Treatments
↑ Wen, Z.; Fang, L. and He, Z. (2009). Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Deliv, 16: 214-223
↑ Engelbrecht, T.; Demé, B.; Dobner, B. and Neubert, R. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7

External links

Isopropyl myristate in the Consumer Product Information Database

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[1] MSDS for isopropyl myristate

[2] Anti-Lice Treatments

[3] Wen, Z.; Fang, L. and He, Z. (2009). Effect of chemical enhancers on percutaneous absorption of daphnetin in isopropyl myristate vehicle across rat skin in vitro. Drug Deliv, 16: 214-223

[4] Engelbrecht, T.; Demé, B.; Dobner, B. and Neubert, R. (2012). Study of the influence of the penetration enhancer isopropyl myristate on the nanostructure of stratum corneum lipid model membranes using neutron diffraction and deuterium labelling. Skin Pharmacol Physiol, 25:200-7