Isopropyl Myristate

Isopropyl myristate^[1]
Names
	Preferred IUPAC name Propan-2-yl tetradecanoate
	Other names Tetradecanoic acid, 1-methylethyl ester; Myristic acid isopropyl ester
Identifiers
CAS Number	110-27-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL207602;
ChemSpider	7751 ;
EC Number	203-751-4;
KEGG	D02296 ;
MeSH	C008205
PubChem CID	8042;
RTECS number	XB8600000;
UNII	0RE8K4LNJS ;
	InChI InChI=1S/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 Key: AXISYYRBXTVTFY-UHFFFAOYSA-N ; InChI=1/C17H34O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-17(18)19-16(2)3/h16H,4-15H2,1-3H3 Key: AXISYYRBXTVTFY-UHFFFAOYAN;
	SMILES CCCCCCCCCCCCCC(=O)OC(C)C;
Properties
Chemical formula	C17H34O2
Molar mass	270.457 g·mol−1
Density	0.85 g/cm3
Boiling point	167 °C (333 °F; 440 K) at 9 mmHg
Hazards
NFPA 704 (fire diamond)	1 0 0
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Isopropyl myristate (IPM) is the ester of isopropyl alcohol and myristic acid. It is a colorless and odorless liquid that is a common ingredient in pharmaceutical and cosmetic preparations.^[2]

Uses

Isopropyl myristate is a polar emollient and is used in cosmetic and topical pharmaceutical preparations as a penetration enhancer where skin absorption is desired.^[3]

It is also used as a treatment for head lice.^[4] It is also in flea and tick killing products for pets.

It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".

Isopropyl myristate is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.

Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid is theorized to be responsible for decreasing of the pH value of formulations.^[5]^[6]

Adverse effects

Isopropyl myristate is frequently classified as a comedogenic compound and may worsen acne vulgaris and promote the development of open and closed comedones, especially when used in high concentrations. This effect is largely attributed to follicular hyperkeratosis, a process where the compound induces an abnormal accumulation of keratinocytes that forms a plug and causes an obstruction within a hair follicle.^[3]