Iodine (125I) Human Albumin

Iodine (¹²⁵I) human albumin
Clinical data
Trade names	Jeanatope
AHFS/Drugs.com	FDA Professional Drug Information
Routes of; administration	Intravenous injection
ATC code	V09GB02 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Elimination half-life	~14 days
Excretion	via kidneys
Identifiers
PubChem SID	17396952;
DrugBank	DB09429;
UNII	68WQQ3N9TI;
KEGG	D02794;

Short description: Iodinated I-125 human serum albumin

Iodine (¹²⁵I) human albumin (trade name Jeanatope) is human serum albumin iodinated with iodine-125, typically injected to aid in the determination of total blood and plasma volume.^[1]^[2]

Iodine-131 iodinated albumin (trade name Volumex) is used for the same purposes.^[3]

Medical uses

Iodine (¹²⁵I) human albumin is used to determine a person's blood volume. For this purpose, a defined amount of radioactivity in form of this drug is injected into a vein, and blood samples are drawn from a different body location after five and fifteen minutes. From the radioactivity of these samples, the original radioactivity per blood volume can be calculated; and knowing the total amount of radioactivity injected, one can calculate the total blood volume.^[1]

It can also be used to calculate the blood plasma volume using a similar method. The main difference is that the drawn blood sample has to be centrifuged to separate the plasma from the blood cells.^[1]

Contraindications

The US Food and Drug Administration lists no contraindications for this drug.^[1]

Adverse effects

There is a theoretical possibility of allergic reactions after repeated use of this medication.^[1]

Pharmacokinetics

Iodine-125 is a radioactive isotope of iodine that decays by electron capture with a physical half-life of 60.14 days. The biological half-life in normal individuals for iodine (¹²⁵I) human albumin has been reported to be approximately 14 days. Its radioactivity is excreted almost exclusively via the kidneys.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Jeanatope FDA Professional Drug Information. Accessed 21 April 2021.
↑ DrugBank DB09429 . Accessed 21 April 2021.
↑ Volumex Injection FDA Professional Drug Information. Accessed 21 April 2021.

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Original source: https://en.wikipedia.org/wiki/Iodine (125I) human albumin. Read more

[Drugs.com-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Jeanatope FDA Professional Drug Information. Accessed 21 April 2021.

[2] DrugBank DB09429 . Accessed 21 April 2021.

[3] Volumex Injection FDA Professional Drug Information. Accessed 21 April 2021.