Selective Receptor Modulator

Selective receptor modulator
Drug class
Tamoxifen, a SERM and a widely used drug in the treatment of breast cancer.
Class identifiers
Synonyms	SRM
Use	Various
Biological target	Steroid hormone receptor
Chemical class	Steroidal; Nonsteroidal

In the field of pharmacology, a selective receptor modulator or SRM is a type of drug that has different effects in different tissues.^[1] A SRM may behave as an agonist in some tissues while as an antagonist in others. Hence selective receptor modulators are sometimes referred to as tissue selective drugs or mixed agonists / antagonists. This tissue selective behavior is in contrast to many other drugs that behave either as agonists or antagonists regardless of the tissue in question.

Classes of selective receptor modulators include:

• Selective androgen receptor modulator (SARM)
• Selective estrogen receptor modulator (SERM)
• Selective glucocorticoid receptor modulator (SEGRM)
• Selective progesterone receptor modulator (SPRM)
• Selective PPAR modulator (SPPARM) including SPPARMγ (affecting the PPARγ) and SPPARMα (PPARα)

• Agonist–antagonist
• Selective glucocorticoid receptor agonist (SEGRA)

0.00 (0 votes) Original source: https://en.wikipedia.org/wiki/Selective receptor modulator. Read more