Mucosal Melanoma

Mucosal Melanoma
Acute radiation mucositis at the palate and acute radiation dermatitis were observed, both of which were classified as grade 2 based on the Common Terminology Criteria for Adverse Events, version 4.0. a Grade 2 acute radiation mucositis occurred shortly after carbon ion radiotherapy administration. b Grade 2 acute radiation dermatitis occurred 2 weeks after carbon ion radiotherapy administration
Pronunciation	\ myü-ˈkō-zəl, \ ˌme-lə-ˈnō-mə
Specialty	Oncology, pathology, dermatology, gynecology, gastroenterology
Symptoms	malaise, fatigue, bleeding, diarrhea, constipation, nose bleeds, skin discoloration, itching, discharge, ulcers, anosmia, hyposmia, skin irritation, canker sores, bloody stools, bloody urine, gum disease, rosacea
Complications	distant and/or microscopic metastasis
Types	mucosal melanoma of the head and neck, vulvar melanoma, vaginal melanoma, anorectal melanoma
Causes	smoking, carcinogens, genetics, chemicals, CID, HIV
Diagnostic method	biopsy, colonoscopy
Treatment	radiation, chemotherapy, surgery

Mucosal melanoma is a rare condition characterized by a melanoma of the mucous membranes. This subtype is associated a worse prognosis than those arising from the skin.^{[1]: 696 [2]} Mucosal melanomas occur in the head and neck (55%), anorectal (24%) and vulvovaginal region (18%), and in the urinary tract (3%).^[3] Based on the histopathologic and clinical features, melanomas of the vulva and vagina are often considered a separate disease entity.^[4] The prognosis of vulvovaginal melanomas is poor, especially for vaginal melanomas and has not improved over the last decades.^[5] While chemotherapy does not improve survival, checkpoint inhibitors have been tested in mucosal melanomas and have shown promising response rates.^[6][7]

See also[edit | edit source]

• Melanoma

References[edit | edit source]

External links[edit | edit source]

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