Citric Acid Cycle

The citric acid cycle is an ingenious series of reactions that oxidizes the acetyl group of acetyl-CoA to two molecules of CO₂ in a manner that conserves the liberated free energy for utilization in ATP generation.

Reactions of the Cycle[edit]

Historical Perspective[edit]

Metabolic Sources of Acetyl-Coenzyme A[edit]

Pyruvate Dehydrogenase Multienzyme Complex[edit]

Control of Pyruvate Dehydrogenase[edit]

Enzymes of the Citric Acid Cycle[edit]

Citrate Synthase[edit]

Aconitase[edit]

NAD⁺-Dependent Isocitrate Dehydrogenase[edit]

α-Ketoglutarate Dehydrogenase[edit]

Succinyl-CoA Synthetase[edit]

Succinate Dehydrogenase[edit]

Fumarase[edit]

Malate Dehydrogenase[edit]

Integration of the Citric Acid Cycle[edit]

Regulation of the Citric Acid Cycle[edit]

The Amphibolic Nature of the Citric Acid Cycle[edit]