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1. Tyrosine kinase inhibitor: A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades. (Chemistry) [100%] 2023-12-14 [Tyrosine kinase inhibitors]
2. Tyrosine kinase: A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Tyrosine kinases are a subgroup of the larger class of protein kinases. [85%] 2023-08-10 [EC 2.7.1]
3. Tyrosine kinase: A tyrosine kinase is an enzyme which catalyzes the transfer of a phosphate group from adenosine triphosphate(ATP) to the hydroxyl oxygen atom on the amino acid tyrosine. This process is known as tyrosine phosphorylation. [85%] 2023-06-10
4. Kinase tyrosine-based inhibitory motif: The term Kinase tyrosine-based inhibitory motif (KTIM) was coined by a group of immunology researchers from McGill University, Montreal, Quebec, Canada in 2008 to represent any immunoreceptor tyrosine-based inhibitory-like sequence motif, with the consensus sequence I/V ... (Type of motif in immunology) [77%] 2024-02-04 [Immunology]
5. Bcr-Abl tyrosine-kinase inhibitor: Bcr-Abl tyrosine-kinase inhibitors (TKI) are the first-line therapy for most patients with chronic myelogenous leukemia (CML). More than 90% of CML cases are caused by a chromosomal abnormality that results in the formation of a so-called ... (Medicine) [77%] 2023-12-14 [Medical treatments]
6. TEK tyrosine kinase: Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor. [69%] 2024-01-26 [Clusters of differentiation] [Tyrosine kinase receptors]...
7. Receptor tyrosine kinase: Articles Most recent articles on Receptor tyrosine kinase Most cited articles on Receptor tyrosine kinase Review articles on Receptor tyrosine kinase Articles on Receptor tyrosine kinase in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Receptor tyrosine kinase ... [69%] 2023-03-12 [Tyrosine kinase receptors]
8. Receptor tyrosine kinase: Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. (Class of enzymes) [69%] 2023-10-28 [Tyrosine kinase receptors] [Single-pass transmembrane proteins]...
9. TEK tyrosine kinase: Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor. [69%] 2023-04-04 [Clusters of differentiation] [Tyrosine kinase receptors]...
10. Tyrosine kinase 2: Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). [69%] 2023-03-08 [Signal transduction] [Tyrosine kinases]...
11. Rho kinase inhibitor: Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. Clinical trials have found that inhibition of the ROCK pathway contributes to the cardiovascular ... (Chemistry) [64%] 2023-12-14 [Protein kinase inhibitors]
12. Protein kinase inhibitor: A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO4, group) to a protein and can modulate its ... (Chemistry) [64%] 2023-12-16 [Protein kinase inhibitors]
13. Tyrosine: Tyrosine, abbreviated Tyr or Y, is one of the twenty common α {\displaystyle \alpha } -amino acids used by living organisms to build proteins. It is one of the four aromatic amino acids together with histidine, phenylalanine and tryptophan. [61%] 2022-09-10
14. Tyrosine: Absorbance and fluorescence of tyrosine in water/buffer Tyrosine is an α-amino acid that is found in most proteins (such as insulin), is normally readily converted from the essential amino acid phenylalanine in the human body, and is a precursor ... [61%] 2023-02-04
15. Tyrosine: L-Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. (Chemistry) [61%] 2023-06-03 [Proteinogenic amino acids] [Glucogenic amino acids]...
16. Tyrosine: L-Tyrosine or tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins. It is a non-essential amino acid with a polar side group. (Amino acid) [61%] 2023-11-19 [Proteinogenic amino acids] [Glucogenic amino acids]...
17. Leukocyte receptor tyrosine kinase: Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown. (Biology) [60%] 2024-01-19
18. Tyrosine-protein kinase BLK: Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene. The tyrosine-protein kinase BLK has been shown to interact with UBE3A. [60%] 2023-03-11 [Tyrosine kinases]
19. Tyrosine kinase de Bruton: La tyrosine kinase de Bruton (Btk ou BTK) est une tyrosine kinase qui est codée par le gène BTK chez l'humain. Elle joue un rôle crucial dans le développement des lymphocytes B. [60%] 2024-05-21
20. AXL receptor tyrosine kinase: Tyrosine-protein kinase receptor UFO is a protein that in human is encoded by the AXL gene. The gene was initially designated as UFO, in allusion to the unidentified function of this protein. (Protein-coding gene in the species Homo sapiens) [60%] 2024-09-23 [Tyrosine kinase receptors]