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Histone deacetylase inhibitor: Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally silenced euchromatin, HDIs can render chromatin more transcriptionally active and induce epigenomic changes. (Compounds that inhibit histone deacetylases) [100%] 2024-04-24 [Histone deacetylase inhibitors] [Antineoplastic drugs]...
Histone deacetylase: Editor-In-Chief: C. Michael Gibson, M.S., M.D. [71%] 2023-04-28
Histone deacetylase: Segestria may refer to. (Class of enzymes important in regulating DNA transcription) [71%] 2024-02-11 [EC 3.5.1]
Histone deacetylase: Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the ... (Biology) [71%] 2024-05-20 [EC 3.5.1]
Inheritors (play): Inheritors is a four-act play written by the American dramatist Susan Glaspell, first performed in 1921 (103 years ago) (1921). The play concerns the legacy of an idealistic farmer who wills his highly coveted midwest farmland to the establishment ... (Play) [64%] 2024-01-01 [1921 plays] [Plays by Susan Glaspell]...
Methylumbelliferyl-acetate deacetylase: The enzyme methylumbelliferyl-acetate deacetylase (EC 3.1.1.56, esterase D) catalyzes the reaction This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is 4-methylumbelliferyl-acetate acylhydrolase. (Biology) [58%] 2023-01-17 [EC 3.1.1] [Enzymes of unknown structure]...
N-acetylglucosamine deacetylase: In enzymology, a N-acetylglucosamine deacetylase (EC 3.5.1.33) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and H2O, whereas its two products are D-glucosamine ... [58%] 2022-10-02 [EC 3.5.1] [Enzymes of known structure]...
6-acetylglucose deacetylase: The enzyme 6-acetylglucose deacetylase (EC 3.1.1.33) catalyzes the reaction This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 6-acetyl-D-glucose ... (Class of enzymes) [58%] 2023-09-12 [EC 3.1.1] [Enzymes of unknown structure]...
PCSK9 inhibitors: PCSK9 inhibitors are a class of medications used to treat hypercholesterolemia. In those on high doses of statins, they decrease risk of further problems by 1.5% over 2.5 years. [57%] 2024-01-01
PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... (Chemistry) [57%] 2023-12-17 [Protein kinase inhibitors]
PERK inhibitors: A PERK inhibitor is a small molecule compound that unlike any existing drug inhibits the expression of protein kinase RNA–like endoplasmic reticulum kinase. The (first such) inhibitor demonstrated the ability to halt brain cell death in mice with prion ... [57%] 2024-02-11 [Protein kinase inhibitors]
Lipase inhibitors: Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. Lipases are secreted by the pancreas when fat is present. [57%] 2023-12-19 [Lipase inhibitors] [Obesity]...
Protease inhibitors: Protease inhibitors (PIs) are a class of medication used to treat or prevent infection by viruses, including HIV and Hepatitis C. PIs prevent viral replication by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to ... [57%] 2023-10-09 [Antivirals] [Antiretroviral drugs]...
Phosphodiesterase inhibitors: Articles Most recent articles on Phosphodiesterase inhibitors Most cited articles on Phosphodiesterase inhibitors Review articles on Phosphodiesterase inhibitors Articles on Phosphodiesterase inhibitors in N Eng J Med, Lancet, BMJ Media Powerpoint slides on Phosphodiesterase inhibitors Images of Phosphodiesterase inhibitors Photos ... [57%] 2023-12-20 [Phosphodiesterase inhibitors] [Drugs]...
STAT inhibitors: STAT inhibitors are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of cytoplasmic induction factors. Inhibitors of STAT proteins are being developed for use in cancer therapy. (Chemistry) [57%] 2023-12-15 [Enzyme inhibitors]
Angiokinase inhibitors: Angiokinase inhibitors are a new therapeutic target for the management of cancer. They inhibit tumour angiogenesis, one of the key processes leading to invasion and metastasis of solid tumours, by targeting receptor tyrosine kinases. (Chemistry) [57%] 2023-12-16 [Tyrosine kinase inhibitors]
Angiokinase inhibitors: Angiokinase inhibitors are a new therapeutic target for the management of cancer. They inhibit tumour angiogenesis, one of the key processes leading to invasion and metastasis of solid tumours, by targeting receptor tyrosine kinases. [57%] 2023-12-20 [Tyrosine kinase inhibitors]
STAT inhibitors: STAT inhibitors are drugs which target signal transducer and activator of transcription (STAT) proteins, a family of cytoplasmic induction factors. Inhibitors of STAT proteins are being developed for use in cancer therapy. (Drug class) [57%] 2024-09-01 [Enzyme inhibitors]
Glycosphingolipid deacylase: In enzymology, a glycosphingolipid deacylase (EC 3.5.1.69) is an enzyme that catalyzes a chemical reaction that cleaves gangliosides and neutral glycosphingolipids, releasing fatty acids to form the lyso-derivatives. This enzyme belongs to the family of hydrolases ... [55%] 2023-06-02 [EC 3.5.1] [Enzymes of unknown structure]...